Mitochondrial ATP-Sensitive Potassium Channel: A Novel Site for Neuroprotection
نویسندگان
چکیده
منابع مشابه
Cardioprotective effects mitochondrial ATP-sensitive potassium channel in exercise conditioning.
We investigated the mitochondrial ATP-sensitive potassium channel [mito-K (ATP)] in exercise preconditioning of myocardial ischemia-reperfusion injury in rats. Eighty SD rats were randomly divided into high-, moderate-, low-intensity, and control groups. The exercise groups were divided into control and inhibited groups. The control group was divided into model and sham groups. Eight rats were ...
متن کاملIdentification and properties of a novel intracellular (mitochondrial) ATP-sensitive potassium channel in brain.
Protection of heart against ischemia-reperfusion injury by ischemic preconditioning and K(ATP) channel openers is known to involve the mitochondrial ATP-sensitive K(+) channel (mitoK(ATP)). Brain is also protected by ischemic preconditioning and K(ATP) channel openers, and it has been suggested that mitoK(ATP) may also play a key role in brain protection. However, it is not known whether mitoK(...
متن کاملA novel mitochondrial K(ATP) channel assay.
RATIONALE The mitochondrial ATP sensitive potassium channel (mK(ATP)) is implicated in cardioprotection by ischemic preconditioning (IPC), but the molecular identity of the channel remains controversial. The validity of current methods to assay mK(ATP) activity is disputed. OBJECTIVE We sought to develop novel methods to assay mK(ATP) activity and its regulation. METHODS AND RESULTS Using a...
متن کاملStructure of a Pancreatic ATP-Sensitive Potassium Channel
ATP-sensitive potassium channels (KATP) couple intracellular ATP levels with membrane excitability. These channels play crucial roles in many essential physiological processes and have been implicated extensively in a spectrum of metabolic diseases and disorders. To gain insight into the mechanism of KATP, we elucidated the structure of a hetero-octameric pancreatic KATP channel in complex with...
متن کاملMCC-134, a single pharmacophore, opens surface ATP-sensitive potassium channels, blocks mitochondrial ATP-sensitive potassium channels, and suppresses preconditioning.
BACKGROUND MCC-134 (1-[4-(H-imidazol-1-yl)benzoyl]-N-methylcyclobutane-carbothioamide), a newly developed analog of aprikalim, opens surface smooth muscle-type ATP-sensitive potassium (K(ATP)) channels but inhibits pancreatic K(ATP) channels. However, the effects of MCC-134 on cardiac surface K(ATP) channels and mitochondrial K(ATP) (mitoK(ATP)) channels are unknown. A mixed agonist/blocker wit...
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ژورنال
عنوان ژورنال: Investigative Opthalmology & Visual Science
سال: 2003
ISSN: 1552-5783
DOI: 10.1167/iovs.02-0815